Tumor screening for Lynch Syndrome

由 JM Carethers 著作 · 2019 · 被引用 7 次 — Lynch syndrome is one of five human conditions in which tumors manifest a defect in MMR function that can be detected by microsatellite instability (MSI) ...

Cancers associated with Lynch syndrome frequently have a specific pattern of mutations known as microsatellite instability (MSI), also known as mismatch repair ...

由 V Roudko 著作 · 2021 · 被引用 50 次 — Lynch syndrome or hereditary non-polyposis colorectal cancer (HNPCC) is characterized by germline inactivation of one allele of genes involved ...

High microsatellite instability (MSI-H) in tumor tissue is a hallmark of Lynch syndrome. MSI-H status indicates that certain sections of DNA called ...

由 CR Boland 著作 · 2010 · 被引用 2545 次 — MSI is detected in about 15% of all colorectal cancers; 3% are of these are associated with Lynch syndrome and the other 12% are caused by sporadic, acquired ...

由 A Latham 著作 · 2019 · 被引用 505 次 — ... Lynch syndrome (LS)-associated cancer predisposition. The recent success of immunotherapy in high-frequency MSI (MSI-H) and/or MMR-D tumors ...

由 K Li 著作 · 2020 · 被引用 379 次 — A study of Skeldon et al. [60] has indicated that patients with MSI-H Lynch syndrome have a rising risk of bladder cancer because of hMSH2 ...

All involve the testing of tumor tissue. MSI: Approximately 90% of colon tumors from individuals with Lynch Syndrome demonstrate microsatellite instability (MSI) ...